Human Recombinant ALK5 Extracellular Domain

• Description:

  Human Recombinant ALK5 Extracellular Domain _x000D_ Catalog number: B2016969_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 µg_x000D_ Molecular Weight or Concentration: 38.1 kDa_x000D_ Supplied as: Powder_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: Activin Receptor-like Kinase 5, Serine/threonine Protein Kinase Receptor 4, SKR4, TGF-βRI, Transforming Growth Factor β Receptor Type I_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Ungefroren H, Groth S, Ruhnke M, Kalthoff H, Fändrich F. Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta J Biol Chem. 2005 Jan 28;280(4):2644-52._x000D_ 2: Zhang Y, Zhang J, Navrazhina K, Argaw AT, Zameer A, Gurfein BT, Brosnan CF, John GR. TGFbeta1 induces Jagged1 expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation Glia. 2010 Jun;58(8):964-74._x000D_ 3: Radwanska A, Cottage CT, Piras A, Overed-Sayer C, Sihlbom C, Budida R, Wrench C, Connor J, Monkley S, Hazon P, Schluter H, Thomas MJ, Hogaboam CM, Murray LA. Increased expression and accumulation of GDF15 in IPF extracellular matrix contribute to fibrosis JCI Insight. 2022 Aug 22;7(16):e153058._x000D_ 4: Asano Y. Future treatments in systemic sclerosis J Dermatol. 2010 Jan;37(1):54-70._x000D_ 5: Guo W, Fan Z, Wang S, Du J. ALK5 is essential for tooth germ differentiation during tooth development Biotech Histochem. 2019 Oct;94(7):481-490._x000D_ 6: Cave DD, Buonaiuto S, Sainz B Jr, Fantuz M, Mangini M, Carrer A, Di Domenico A, Iavazzo TT, Andolfi G, Cortina C, Sevillano M, Heeschen C, Colonna V, Corona M, Cucciardi A, Di Guida M, Batlle E, De Luca A, Lonardo E. LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer J Exp Clin Cancer Res. 2022 Oct 26;41(1):315._x000D_ 7: Azuma H. Genetic and molecular pathogenesis of hereditary hemorrhagic telangiectasia J Med Invest. 2000 Aug;47(3-4):81-90._x000D_ 8: Zhao HJ, Klausen C, Li Y, Zhu H, Wang YL, Leung PCK. Bone morphogenetic protein 2 promotes human trophoblast cell invasion by upregulating N-cadherin via non-canonical SMAD2/3 signaling Cell Death Dis. 2018 Feb 7;9(2):174._x000D_ 9: Chen YC, Chang HM, Cheng JC, Tsai HD, Wu CH, Leung PC. Transforming growth factor-β1 up-regulates connexin43 expression in human granulosa cells Hum Reprod. 2015 Sep;30(9):2190-201._x000D_ 10: Cadenas J, Pors SE, Kumar A, Kalra B, Kristensen SG, Andersen CY, Mamsen LS. Concentrations of oocyte secreted GDF9 and BMP15 decrease with MII transition during human IVM Reprod Biol Endocrinol. 2022 Aug 19;20(1):126. _x000D_ _x000D_ Products Related to Human Recombinant ALK5 Extracellular Domain can be found at Proteins

• Short Description:

  Catalog Number: B2016969 (50 µg)

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3