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PDE4-IN-22

CAT: 0804-HY-168212Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168212Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDE4-IN-22 (Compound 2e) is a PDE4 inhibitor with an IC50 value of 2.4 nM. PDE4-IN-22 exhibits anti-inflammatory activity and demonstrates significant anti-psoriatic effects in an Imiquimod -induced psoriasis mouse model[1].
UNSPSC
12352005
Target
Interleukin Related; Phosphodiesterase (PDE) ; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pde4-in-22.html
Smiles
O=C(C1=CNC(C2=CC=C(OC(F)F)C(OCC3CC3)=C2)=N1)NCC4=CC(F)=CC=C4F
Molecular Formula
C22H19F4N3O3
Molecular Weight
449.40
References & Citations
[1]Li G, et al. Development of selective heterocyclic PDE4 inhibitors for treatment of psoriasis[J]. European Journal of Medicinal Chemistry, 2024, 280: 116930.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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