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Antitumor agent-143

CAT: 0804-HY-161332Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161332Size:1 Each
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Description
Antitumor agent-143 (compound 2c) is an antitumor agent that blocks cell proliferation of A549 cells during the S phase and induces an early apoptosis. Antitumor agent-143 induces cell death via ferroptosis, apoptosis by a ROS-mediated mitochondrial dysfunction pathway and GSDMD-mediated pyroptosis[1].
CAS Number
9007-83-4
UNSPSC
12352005
Target
Apoptosis; Ferroptosis; Pyroptosis; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-143.html
Solubility
10 mM in DMSO
Smiles
F[P-](F)(F)(F)(F)F.NC(N=C1Cl)=NC(Cl)=C1C(N2)=NC3=C2C(C=CC=[N]45)=C5C6=C3C=CC=[N]6[Ir]74([N]8=C9C(C=CC=C%10)=C%10C=C8)(C%11=C9C=CC=C%11)[N]%12=C(C%13=CC=CC=C%137)C%14=C(C=CC=C%14)C=C%12
Molecular Formula
C47H29Cl2F6IrN9P
Molecular Weight
1127.88
References & Citations
[1]Huiyan Hu, et al. Synthesis and mitochondria-localized iridium (III) complexes induce cell death through pyroptosis and ferroptosis pathways. Eur J Med Chem. 2024 Feb 29:268:116295.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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