Nrf2 activator 18
CAT:
804-HY-168709
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Nrf2 activator 18
- UNSPSC Description: Nrf2 activator 18 (Compound 11a) is an orally active activator for Keap1/Nrf2/HO-1 signaling pathway, that promotes the Nrf2 nuclear translocation, and enhances the antioxidant efficacy. Nrf2 activator 18 inhibits the release of IL-6 with an IC50 of 4.816 μM. Nrf2 activator 18 exhibits anti-inflammatory efficacy in mouse PM2.5-induced lung injury model[1].
- Target Antigen: Keap1-Nrf2
- Type: Reference compound
- Related Pathways: NF-κB
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/nrf2-activator-18.html
- Smiles: CN(C(C1=NN(C(C(C)(C)C)=C1)C2=CC=C(C=C2)F)=O)/C=C\C3=CC=CC=C3
- Molecular Weight: 377.45
- References & Citations: [1]Zhang G, et al., Synthesis, evaluation and mechanism study of novel pyrazole enamides to alleviate lung injury. Eur J Med Chem. 2025 Jan 15;282:117068.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported