Nrf2 activator 18

• UNSPSC Description:

  Nrf2 activator 18 (Compound 11a) is an orally active activator for Keap1/Nrf2/HO-1 signaling pathway, that promotes the Nrf2 nuclear translocation, and enhances the antioxidant efficacy. Nrf2 activator 18 inhibits the release of IL-6 with an IC50 of 4.816 μM. Nrf2 activator 18 exhibits anti-inflammatory efficacy in mouse PM2.5-induced lung injury model[1].

• Target Antigen:

  Keap1-Nrf2

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/nrf2-activator-18.html

• Smiles:

  CN(C(C1=NN(C(C(C)(C)C)=C1)C2=CC=C(C=C2)F)=O)/C=C\C3=CC=CC=C3

• Molecular Weight:

  377.45

• References & Citations:

  [1]Zhang G, et al., Synthesis, evaluation and mechanism study of novel pyrazole enamides to alleviate lung injury. Eur J Med Chem. 2025 Jan 15;282:117068.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported