Nrf2 activator-9

• UNSPSC Description:

  Nrf2 activator-9 (compound D-36) is an Nrf2 activator that inhibits oxidized low-density lipoprotein (oxLDL) and high glucose (HG)-induced apoptosis in HUVEC cells. Nrf2 activator-9 inhibits oxLDL and HG-induced vascular endothelial cell (VEC) injury and can effectively prevent and treat atherosclerosis[1].

• Target Antigen:

  Apoptosis; Keap1-Nrf2

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;NF-κB

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/nrf2-activator-9.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=CC(/C=C/C(N2CCN(CC2)CC3=NOC(CC4=CNC5=CC=CC=C54)=N3)=O)=CC=C1OC

• Molecular Weight:

  473.52

• References & Citations:

  [1]Zhang J, et al. Discovery of marine phidianidine-based Nrf2 activators and their potential against oxLDL- and HG-induced injury in HUVECs. Bioorg Med Chem Lett. 2023 Sep 7;95:129468.. .

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported