Nrf2 activator-9

Nrf2 activator-9

• UNSPSC Description: Nrf2 activator-9 (compound D-36) is an Nrf2 activator that inhibits oxidized low-density lipoprotein (oxLDL) and high glucose (HG)-induced apoptosis in HUVEC cells. Nrf2 activator-9 inhibits oxLDL and HG-induced vascular endothelial cell (VEC) injury and can effectively prevent and treat atherosclerosis[1].
• Target Antigen: Apoptosis; Keap1-Nrf2
• Type: Reference compound
• Related Pathways: Apoptosis;NF-κB
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/nrf2-activator-9.html
• Solubility: 10 mM in DMSO
• Smiles: OC1=CC(/C=C/C(N2CCN(CC2)CC3=NOC(CC4=CNC5=CC=CC=C54)=N3)=O)=CC=C1OC
• Molecular Weight: 473.52
• References & Citations: [1]Zhang J, et al. Discovery of marine phidianidine-based Nrf2 activators and their potential against oxLDL- and HG-induced injury in HUVECs. Bioorg Med Chem Lett. 2023 Sep 7;95:129468.. .
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported