Nrf2 activator-6

• UNSPSC Description:

  Nrf2 activator-6, a tetrahydroisoquinoline compound, is a Nrf2 activator. Nrf2 activator-6 has an IC50 of 5 nM for inhibiting the Kelch domain-Nrf2 interaction (WO2021214470A1; Example 4)[1].

• Target Antigen:

  Keap1-Nrf2

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/nrf2-activator-6.html

• Purity:

  98.15

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  OC([C@@](C)(CCC1)[C@@H]1C(N2[C@H](CN3C(CC4(C3)CC4)=O)C5=C(C(F)=CC(Cl)=C5CC2)OCC6=C7N(CCCC7)N=N6)=O)=O

• Molecular Weight:

  614.11

• References & Citations:

  [1]Cathy Louise LUCAS, et al. Tetrahydroisoquinoline compounds as nrf2 activators. WO2021214470A1.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  2728780-74-1