Nrf2 activator-5

Nrf2 activator-5

• CAS Number: 1012860-13-7
• UNSPSC Description: Nrf2 activator-5 (compound 1) is a potent Nrf2 activator that can attenuate H2O2-induced oxidative stress and LPS-stimulated inflammation in BV-2 microglial cells. Nrf2 activator-5 exhibits antioxidant and anti-inflammatory activities[1].
• Target Antigen: Keap1-Nrf2
• Type: Reference compound
• Related Pathways: NF-κB
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/nrf2-activator-5.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@]1(Cl)[C@@]2(C/C=C(C)/CC/C=C(C)/CO)OC(C)(C)[C@H](Cl)C1)C3=C(C2=O)C=C(O)C=C3O
• Molecular Weight: 497.41
• References & Citations: [1]Choi JW, et, al. Identification and evaluation of a napyradiomycin as a potent Nrf2 activator: Anti-oxidative and anti-inflammatory activities. Bioorg Chem. 2020 Dec;105:104434.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported