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Nrf2 activator-5

CAT: 0804-HY-146168Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146168Size:1 Each
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Description
Nrf2 activator-5 (compound 1) is a potent Nrf2 activator that can attenuate H2O2-induced oxidative stress and LPS-stimulated inflammation in BV-2 microglial cells. Nrf2 activator-5 exhibits antioxidant and anti-inflammatory activities[1].
CAS Number
1012860-13-7
UNSPSC
12352005
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nrf2-activator-5.html
Solubility
10 mM in DMSO
Smiles
O=C([C@]1(Cl)[C@@]2(C/C=C(C)/CC/C=C(C)/CO)OC(C)(C)[C@H](Cl)C1)C3=C(C2=O)C=C(O)C=C3O
Molecular Formula
C25H30Cl2O6
Molecular Weight
497.41
References & Citations
[1]Choi JW, et, al. Identification and evaluation of a napyradiomycin as a potent Nrf2 activator: Anti-oxidative and anti-inflammatory activities. Bioorg Chem. 2020 Dec;105:104434.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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