Nrf2 activator-5

• Description:

  Nrf2 activator-5 (compound 1) is a potent Nrf2 activator that can attenuate H2O2-induced oxidative stress and LPS-stimulated inflammation in BV-2 microglial cells. Nrf2 activator-5 exhibits antioxidant and anti-inflammatory activities[1].

• UNSPSC:

  12352005

• Target:

  Keap1-Nrf2

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/nrf2-activator-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@]1(Cl)[C@@]2(C/C=C(C)/CC/C=C(C)/CO)OC(C)(C)[C@H](Cl)C1)C3=C(C2=O)C=C(O)C=C3O

• Molecular Formula:

  C25H30Cl2O6

• Molecular Weight:

  497.41

• References & Citations:

  [1]Choi JW, et, al. Identification and evaluation of a napyradiomycin as a potent Nrf2 activator: Anti-oxidative and anti-inflammatory activities. Bioorg Chem. 2020 Dec;105:104434.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1012860-13-7]