Nrf2 activator-10

• Target:

  Nrf2|||Apoptosis

• Related Pathways:

  Immunology/Inflammation|||Apoptosis

• Bioactivity:

  Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent antioxidant response element (ARE) inducer, with an EC50 of 2.7 ?M, and also acts as an Nrf2 activator. It modifies Keap1, preventing the formation of the Cul3-Keap1 ubiquitin ligase complex, thereby activating Nrf2 transcription. Nrf2 activator-10 provides cellular protection against H2O2-induced apoptosis.

• Smiles:

  O=C(OCC)C=1C(=O)N(C=2C=CC=CC2C1Cl)C

• Molecular Formula:

  C13H12ClNO3

• Molecular Weight:

  265.69

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  75483-04-4