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Nrf2 activator-10

CAT: 0931-T210013-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210013-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
75483-04-4
Target
Nrf2, Apoptosis
Related Pathways
Immunology/Inflammation, Apoptosis
Bioactivity
Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent antioxidant response element (ARE) inducer, with an EC50 of 2.7 μM, and also acts as an Nrf2 activator. It modifies Keap1, preventing the formation of the Cul3-Keap1 ubiquitin ligase complex, thereby activating Nrf2 transcription. Nrf2 activator-10 provides cellular protection against H2O2-induced apoptosis.
Smiles
O=C(OCC)C=1C(=O)N(C=2C=CC=CC2C1Cl)C
Molecular Formula
C13H12ClNO3
Molecular Weight
265.69
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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