Nrf2 activator-21

• Target :

  Nrf2|||Caspase|||Apoptosis

• Related Pathways :

  Proteases/Proteasome|||Apoptosis|||Immunology/Inflammation

• Bioactivity :

  Nrf2 activator-21 is a compound that serves as an Nrf2 activator with both antioxidant and neuroprotective properties. It binds to the Keap1Kelch domain, disrupting the Keap1-Nrf2 interaction and activating antioxidant defense mechanisms. Nrf2 activator-21 decreases apoptosis of hippocampal neurons and reduces caspase-3 activity. It targets cerebral ischemia/reperfusion injury (CIRI) by activating the Nrf2 pathway. The compound improves neurological function, alleviates anxiety-like behavior induced by bilateral carotid artery occlusion (2VO) in rats, and enhances memory. Nrf2 activator-21 is applicable in studies of cerebral ischemia/reperfusion injury.

• Smiles :

  O=C1OC=2C=C(OC)C=CC2C=C1C(=O)C=CC3=CC=C(O)C=C3

• Molecular Formula :

  C19H14O5

• Molecular Weight :

  322.31

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1912404-14-8