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Nrf2 activator-21

CAT: 0931-T212422-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212422-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1912404-14-8
Target
Nrf2, Caspase, Apoptosis
Related Pathways
Proteases/Proteasome, Apoptosis, Immunology/Inflammation
Bioactivity
Nrf2 activator-21 is a compound that serves as an Nrf2 activator with both antioxidant and neuroprotective properties. It binds to the Keap1Kelch domain, disrupting the Keap1-Nrf2 interaction and activating antioxidant defense mechanisms. Nrf2 activator-21 decreases apoptosis of hippocampal neurons and reduces caspase-3 activity. It targets cerebral ischemia/reperfusion injury (CIRI) by activating the Nrf2 pathway. The compound improves neurological function, alleviates anxiety-like behavior induced by bilateral carotid artery occlusion (2VO) in rats, and enhances memory. Nrf2 activator-21 is applicable in studies of cerebral ischemia/reperfusion injury.
Smiles
O=C1OC=2C=C(OC)C=CC2C=C1C(=O)C=CC3=CC=C(O)C=C3
Molecular Formula
C19H14O5
Molecular Weight
322.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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