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TLR8 agonist 9

CAT: 0804-HY-161631Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161631Size:1 Each
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Description
TLR8 agonist 9 (Compound II-77) is an agonist for Toll-like receptor 8 (TLR8) with EC50 of 0.25-1 μM. TLR8 agonist 9 is stable in human and murine plasma, induces secretion of cytokines TNFα, with EC50 [1].
CAS Number
3034750-61-0
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tlr8-agonist-9.html
Smiles
O=C(C=CC1=O)N1CC2OCC(C(N3CCC4=NC=C(NC(C5(CC5)C6=CC=C7C(N=C(N)CC(C(N(CCC)CCO)=O)=C7)=C6)=O)C=C4C3)=O)CO2
Molecular Formula
C38H43N7O8
Molecular Weight
725.79
References & Citations
[1]Zhang W, et al., Benzazepine derivative, conjugate containing same, and use thereof. WO2024067841A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR8

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