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THR-β agonist 9

CAT: 0804-HY-174887Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174887Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
THR-β agonist 9 is a potent, selective, and His435 mutation-sensitive THR-β (EC50: 3.2 nM) agonist. THR-β agonist 9 has moderate selectivity (approximately 10-fold) and good activation capacity (EC50: 134.2 nM to 515.5 nM) for multiple His435 mutants (H435A, H435Y, and H435R) . THR-β agonist 9 has the potential to be used in the study of dyslipidemia, metabolic dysfunction-associated steatohepatitis (MASH), or resistance to thyroid hormone (RTH) [1].
CAS Number
2920045-74-3
UNSPSC
12352005
Target
Acetyl-CoA Carboxylase; AMPK; Mitochondrial Metabolism; Thyroid Hormone Receptor
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Smiles
OC1=C(C(NCC(O)=O)=O)N=C(OC)C2=CC(OC3=CC=C4C(C=CC=C4)=C3)=CC=C21
Molecular Formula
C23H18N2O6
Molecular Weight
418.40
References & Citations
[1]Li Q, et al. Discovery of a Potent, Selective, and Multiple His435 Mutation-Sensitive Thyroid Hormone Receptor β Agonist. J Med Chem. 2025 Jul 10;68 (13) :13471-13490.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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