TLR8 agonist 9

• Target :

  TLR

• Related Pathways :

  Immunology/Inflammation

• Bioactivity :

  TLR8 agonist9 (Compound II-77) functions as an agonist for Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 ?M. This compound is stable in human and mouse plasma and effectively induces the secretion of the cytokine TNF? with an EC50 of less than 1 ?M. In the MC38-HER2 xenograft mouse model, TLR8 agonist9 demonstrates significant antitumor activity, achieving a tumor growth inhibition (TGI) rate of 97%.

• Smiles :

  O=C1C=CC(=O)N1CC2OCC(C(=O)N3CC4=CC(=CN=C4CC3)NC(=O)C5(C=6C=CC=7C=C(C(=O)N(CCO)CCC)CC(=NC7C6)N)CC5)CO2

• Molecular Formula :

  C38H43N7O8

• Molecular Weight :

  725.79

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  3034750-61-0