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TLR7/8 agonist 9

CAT: 0804-HY-153544Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-153544Size:1 Each
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Description
TLR7/8 agonist 9 (Compound 25a) is a TLR7/8 agonist, with EC50s of 40 nM and 23 nM for hTLR7/8. TLR7/8 agonist 9 has anti-tumor activity and improves the antitumor activity of PD-1/PD-L1 blockade. TLR7/8 agonist 9 can be used for research of cancer immunotherapy[1].
CAS Number
2649170-17-0
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tlr7-8-agonist-9.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(NCCOC)=C2C(C=CC(CC3=CC=C(CN(C)C)C=C3)=N2)=N1
Molecular Formula
C20H26N6O
Molecular Weight
366.46
References & Citations
[1]Wang Z, et al. Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer Immunotherapy. J Med Chem. 2021 Jun 10;64 (11) :7507-7532.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR7; TLR8

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