TLR7/8 agonist 9

TLR7/8 agonist 9

• CAS Number: 2649170-17-0
• UNSPSC Description: TLR7/8 agonist 9 (Compound 25a) is a TLR7/8 agonist, with EC50s of 40 nM and 23 nM for hTLR7/8. TLR7/8 agonist 9 has anti-tumor activity and improves the antitumor activity of PD-1/PD-L1 blockade. TLR7/8 agonist 9 can be used for research of cancer immunotherapy[1].
• Target Antigen: Toll-like Receptor (TLR)
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tlr7-8-agonist-9.html
• Solubility: 10 mM in DMSO
• Smiles: NC1=NC(NCCOC)=C2C(C=CC(CC3=CC=C(CN(C)C)C=C3)=N2)=N1
• Molecular Weight: 366.46
• References & Citations: [1]Wang Z, et al. Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer Immunotherapy. J Med Chem. 2021 Jun 10;64(11):7507-7532.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported