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TLR8 agonist 7

CAT: 0931-T88108-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T88108-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3034750-26-7
Target
TLR
Related Pathways
Immunology/Inflammation
Bioactivity
TLR8 agonist7 is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It remains stable in human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist7 demonstrates antitumor activity, achieving a tumor growth inhibition (TGI) rate of 98%.
Smiles
C(NC=1C=C2C(=NC1)CCN(C(OCC3=CC(NC(CNC(CCCCCN4C(=O)C=CC4=O)=O)=O)=C(O[C@@H]5O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]5O)C=C3)=O)C2)(=O)C6(CC6)C=7C=C8C(=CC7)C=C(C(N(CCC)CCO)=O)CC(N)=N8
Molecular Formula
C54H63N9O16
Molecular Weight
1094.13
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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