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BF-168

CAT: 0804-HY-112830-04Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112830-04Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BF-168, a candidate probe for PET, is found to specifically recognize both neuritic and diffuse plaques, with a Ki of 6.4 nM for Aβ1-42.
CAS Number
634911-47-0
UNSPSC
12352005
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/BF-168.html
Purity
99.68
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CNC1=CC=C(/C=C/C2=NC3=CC=C(OCCF)C=C3O2)C=C1
Molecular Formula
C18H17FN2O2
Molecular Weight
312.34
References & Citations
[1]Okamura N, et al. Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain. J Neurosci. 2004 Mar 10;24 (10) :2535-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

6-(2-Fluoroethoxy)-2-(2-(4-methylaminophenil)ethenyl)benzoxazole

binds senile plaques in brain with Alzheimer's; structure in first source

CAS Number634911-47-0
PubChem CID10244995
IUPAC Name4-[(E)-2-[6-(2-fluoroethoxy)-1,3-benzoxazol-2-yl]ethenyl]-N-methylaniline
Molecular FormulaC18H17FN2O2
Molecular Weight312.3
XLogP4.4
Topological Polar Surface Area47.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count23
Formal Charge0
Complexity385
SMILES
CNC1=CC=C(C=C1)/C=C/C2=NC3=C(O2)C=C(C=C3)OCCF
InChI
InChI=1S/C18H17FN2O2/c1-20-14-5-2-13(3-6-14)4-9-18-21-16-8-7-15(22-11-10-19)12-17(16)23-18/h2-9,12,20H,10-11H2,1H3/b9-4+
InChIKey
FJCPWUDGNYOGQR-RUDMXATFSA-N
Chemical Structure
2D Structure
2D structure of 6-(2-Fluoroethoxy)-2-(2-(4-methylaminophenil)ethenyl)benzoxazole
CAS: 634911-47-0
CID: 10244995
Formula: C18H17FN2O2
MW: 312.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight312.3
XLogP34.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass312.12740595
Monoisotopic Mass312.12740595
Topological Polar Surface Area47.3 Ų
Heavy Atom Count23
Formal Charge0
Complexity385
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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