BF-1

• Description:

  BF-1 is a 5-HT2B receptor antagonist with a pKi value of 10.05 and an IC50 value of 2.6 nM[1].

• UNSPSC:

  12352005

• Target:

  5-HT Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bf-1.html

• Smiles:

  CN1CC/C(CC1)=C2C3=C(SC4=C\2C=CC(OCC)=C4)C=CC=C3OC

• Molecular Formula:

  C22H25NO2S

• Molecular Weight:

  367.50

• References & Citations:

  [1]Beate Schmitz, et al. BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 2015 Mar 15:751:73-80.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  5-HT2 Receptor

• CAS Number:

  [518980-66-0]