BF-175

• Description :

  BF-175 is a selective SIRT1 agonist. BF175 increases SIRT1-mediated activation of PGC1-α, induces Apoptosis, induces Autophagy and inhibits SREBP activity. BF-175 protects against high glucose-mediated mitochondrial injury. BF-175 attenuates diabetic kidney disease progression. BF175 inhibits endometrial carcinoma[1][2].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Autophagy; Fatty Acid Synthase (FASN) ; PGC-1α; Sirtuin

• Related Pathways :

  Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

• Field of Research :

  Cancer; Metabolic Disease

• Smiles :

  CC1(OB(C2=CC=C(C=C2)/C=C/C3=CC(Cl)=CC(Cl)=C3)OC1(C)C)C

• Molecular Formula :

  C20H21BCl2O2

• Molecular Weight :

  375.10

• References & Citations :

  [1]Hong Q, et al. Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury. Kidney Int. 2018 Jun;93 (6) :1330-1343. |[2]Wang Q, et al. BF175 inhibits endometrial carcinoma through SREBP-regulated metabolic pathways in vitro. Mol Cell Endocrinol. 2021 Mar 1;523:111135.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  SIRT1

• CAS Number :

  [1333375-02-2]