ETC-168

• Description :

  ETC-168 is a selective and oral active MNK inhibitor with the IC50 values of 23 and 43 nM against MNK1 and MNK2, respectively. ETC-168 shows antiproliferative efficacy in vivo and in vitro[1].

• UNSPSC :

  12352005

• Target :

  MNK

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/etc-168.html

• Solubility :

  10 mM in DMSO

• Smiles :

  N#CC1=CC=C(C2=CN=C3C=CC(C4=CC=C(C(N5CCOCC5)=O)C=C4)=NN32)C=C1

• Molecular Formula :

  C24H19N5O2

• Molecular Weight :

  409.44

• References & Citations :

  [1]Ke XY, et al. MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma. Oncogene. 2021;40 (10) :1851-1867.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MNK1; MNK2

• CAS Number :

  [1464150-99-9]