Anticancer agent 168

• Description :

  Anticancer agent 168 (compound d16) is a inhibitor of DNA2. Anticancer agent 168 induces apoptosis and cell-cycle arrest mainly at S-phase, and exhibits anticancer activities and overcomes chemotherapy resistance in mutp53-bearing cancers[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; DNA/RNA Synthesis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/anticancer-agent-168-1.html

• Purity :

  99.55

• Solubility :

  DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  OC(C1=CN(CC)C2=CC(Cl)=C(C3=CC=C([N+]([O-])=O)O3)C=C2C1=O)=O

• Molecular Formula :

  C16H11ClN2O6

• Molecular Weight :

  362.72

• References & Citations :

  [1]Folly-Kossi H, et al. DNA2 Nuclease Inhibition Confers Synthetic Lethality in Cancers with Mutant p53 and Synergizes with PARP Inhibitors. Cancer Res Commun. 2023;3 (10) :2096-2112.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [207399-56-2]