Anticancer agent 168

Anticancer agent 168

• CAS Number: 9007-83-4
• UNSPSC Description: Anticancer agent 168 (compound d16) is a inhibitor of DNA2. Anticancer agent 168 induces apoptosis and cell-cycle arrest mainly at S-phase, and exhibits anticancer activities and overcomes chemotherapy resistance in mutp53-bearing cancers[1].
• Target Antigen: Apoptosis; DNA/RNA Synthesis
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/anticancer-agent-168-1.html
• Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: OC(C1=CN(CC)C2=CC(Cl)=C(C3=CC=C([N+]([O-])=O)O3)C=C2C1=O)=O
• Molecular Weight: 362.72
• References & Citations: [1]Folly-Kossi H, et al. DNA2 Nuclease Inhibition Confers Synthetic Lethality in Cancers with Mutant p53 and Synergizes with PARP Inhibitors. Cancer Res Commun. 2023;3(10):2096-2112.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported