Anticancer agent 168

• UNSPSC Description:

  Anticancer agent 168 (compound d16) is a inhibitor of DNA2. Anticancer agent 168 induces apoptosis and cell-cycle arrest mainly at S-phase, and exhibits anticancer activities and overcomes chemotherapy resistance in mutp53-bearing cancers[1].

• Target Antigen:

  Apoptosis; DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/anticancer-agent-168-1.html

• Solubility:

  DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  OC(C1=CN(CC)C2=CC(Cl)=C(C3=CC=C([N+]([O-])=O)O3)C=C2C1=O)=O

• Molecular Weight:

  362.72

• References & Citations:

  [1]Folly-Kossi H, et al. DNA2 Nuclease Inhibition Confers Synthetic Lethality in Cancers with Mutant p53 and Synergizes with PARP Inhibitors. Cancer Res Commun. 2023;3(10):2096-2112.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  9007-83-4