BF 227

• Description :

  BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for Aβ1-42 fibrils.

• UNSPSC :

  12352005

• Target :

  Amyloid-β

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/BF_227.html

• Purity :

  98.88

• Solubility :

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles :

  CN(C)C1=NC=C(S1)/C=C/C2=NC3=CC=C(OCCF)C=C3O2

• Molecular Formula :

  C16H16FN3O2S

• Molecular Weight :

  333.38

• References & Citations :

  [1]Kudo Y, et al. Development of amyloid imaging PET probes for an early diagnosis of Alzheimer's disease. Minim Invasive Ther Allied Technol. 2006;15 (4) :209-13.|[2]Furukawa K, et al. Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227: comparison to FDG-PET. J Neurol. 2010 May;257 (5) :721-7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [845647-80-5]