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BF-170

CAT: 0804-HY-W338446Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W338446Size:1 Each
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Description
BF-170 is a selective tau fibril binding agent with an EC50 of 221 nM. It exhibits good blood-brain barrier permeability, and after intravenous injection in mice, the concentration in brain tissue reaches 9.1% ID/g within 2 minutes (with a brain clearance rate of 0.25% ID/g after 30 minutes) . BF-170 can be used as a probe for tau protein pathology imaging in Alzheimer's disease (AD) . It plays an important role in early-stage AD research and holds potential for imaging studies of tau-related neurodegenerative diseases[1].
CAS Number
22191-97-5
UNSPSC
12352005
Hazard Statement
H302-H315-H318-H335
Target
Tau Protein
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
C1=CC=C2C(=C1)C=CC(=N2)C3=CC=C(C=C3)N
Molecular Formula
C15H12N2
Molecular Weight
220.27
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Okamura N, et al. Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease. J Neurosci. 2005 Nov 23;25 (47) :10857-62.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

2-(4-Aminophenyl)quinoline

used for imaging tau protein; structure in first source

CAS Number22191-97-5
PubChem CID297284
IUPAC Name4-quinolin-2-ylaniline
Molecular FormulaC15H12N2
Molecular Weight220.27
XLogP3.2
Topological Polar Surface Area38.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count17
Formal Charge0
Complexity245
SMILES
C1=CC=C2C(=C1)C=CC(=N2)C3=CC=C(C=C3)N
InChI
InChI=1S/C15H12N2/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15/h1-10H,16H2
InChIKey
PWLMSCCFNGGPGM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(4-Aminophenyl)quinoline
CAS: 22191-97-5
CID: 297284
Formula: C15H12N2
MW: 220.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight220.27
XLogP33.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass220.100048391
Monoisotopic Mass220.100048391
Topological Polar Surface Area38.9 Ų
Heavy Atom Count17
Formal Charge0
Complexity245
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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