BF-170

CAT: 0804-HY-W338446Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-W338446Size:1 Each
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Description
BF-170 is a selective tau fibril binding agent with an EC50 of 221 nM. It exhibits good blood-brain barrier permeability, and after intravenous injection in mice, the concentration in brain tissue reaches 9.1% ID/g within 2 minutes (with a brain clearance rate of 0.25% ID/g after 30 minutes) . BF-170 can be used as a probe for tau protein pathology imaging in Alzheimer's disease (AD) . It plays an important role in early-stage AD research and holds potential for imaging studies of tau-related neurodegenerative diseases[1].
CAS Number
[22191-97-5]
UNSPSC
12352005
Hazard Statement
H302-H315-H318-H335
Target
Tau Protein
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
C1=CC=C2C(=C1)C=CC(=N2)C3=CC=C(C=C3)N
Molecular Formula
C15H12N2
Molecular Weight
220.27
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Okamura N, et al. Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease. J Neurosci. 2005 Nov 23;25 (47) :10857-62.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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