P-gp modulator-4

• Description:

  P-gp modulator-4 (compound 4c) inhibits the efflux function of P-glycoprotein (P-gp) . P-gp modulator-4 shows multidrug resistance (MDR) in cancer reversal activity (IC50 of Paclitaxel (HY-B0015) = 8.80, reversal fold = 211.8) [1].

• UNSPSC:

  12352005

• Target:

  P-glycoprotein

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/p-gp-modulator-4.html

• Smiles:

  CC (C) (O) [C@H] (O1) CC[C@@]1 (C) [C@@]2 ([H]) CC[C@@]3 (C) [C@]4 (C) CC[C@@]5 ([H]) C (C) (C) [C@@H] (NC (CC6CN (C (OC (C) (C) C) =O) C6) =O) CC[C@]5 (C) [C@@]4 ([H]) C[C@@H] (O) [C@@]32[H]

• Molecular Formula:

  C40H68N2O6

• Molecular Weight:

  672.98

• References & Citations:

  [1]Liping Yu, et al. Novel pyxinol amide derivatives bearing an aliphatic heterocycle as P-glycoprotein modulators for overcoming multidrug resistance. Eur J Med Chem. 2024 Jun 5:272:116466.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported