P-gp modulator-4

P-gp modulator-4

• UNSPSC Description: P-gp modulator-4 (compound 4c) inhibits the efflux function of P-glycoprotein (P-gp). P-gp modulator-4 shows multidrug resistance (MDR) in cancer reversal activity (IC50 of Paclitaxel (HY-B0015) = 8.80, reversal fold = 211.8)[1].
• Target Antigen: P-glycoprotein
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/p-gp-modulator-4.html
• Smiles: CC(C)(O)[C@H](O1)CC[C@@]1(C)[C@@]2([H])CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](NC(CC6CN(C(OC(C)(C)C)=O)C6)=O)CC[C@]5(C)[C@@]4([H])C[C@@H](O)[C@@]32[H]
• Molecular Weight: 672.98
• References & Citations: [1]Liping Yu, et al. Novel pyxinol amide derivatives bearing an aliphatic heterocycle as P-glycoprotein modulators for overcoming multidrug resistance. Eur J Med Chem. 2024 Jun 5:272:116466.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported