P-gp modulator-4

CAT: 0804-HY-161645Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-161645Size:1 Each
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Description
P-gp modulator-4 (compound 4c) inhibits the efflux function of P-glycoprotein (P-gp) . P-gp modulator-4 shows multidrug resistance (MDR) in cancer reversal activity (IC50 of Paclitaxel (HY-B0015) = 8.80, reversal fold = 211.8) [1].
UNSPSC
12352005
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p-gp-modulator-4.html
Smiles
CC(C)(O)[C@H](O1)CC[C@@]1(C)[C@@]2([H])CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](NC(CC6CN(C(OC(C)(C)C)=O)C6)=O)CC[C@]5(C)[C@@]4([H])C[C@@H](O)[C@@]32[H]
Molecular Formula
C40H68N2O6
Molecular Weight
672.98
References & Citations
[1]Liping Yu, et al. Novel pyxinol amide derivatives bearing an aliphatic heterocycle as P-glycoprotein modulators for overcoming multidrug resistance. Eur J Med Chem. 2024 Jun 5:272:116466.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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