P-gp modulator-4

• UNSPSC Description:

  P-gp modulator-4 (compound 4c) inhibits the efflux function of P-glycoprotein (P-gp). P-gp modulator-4 shows multidrug resistance (MDR) in cancer reversal activity (IC50 of Paclitaxel (HY-B0015) = 8.80, reversal fold = 211.8)[1].

• Target Antigen:

  P-glycoprotein

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/p-gp-modulator-4.html

• Smiles:

  CC(C)(O)[C@H](O1)CC[C@@]1(C)[C@@]2([H])CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](NC(CC6CN(C(OC(C)(C)C)=O)C6)=O)CC[C@]5(C)[C@@]4([H])C[C@@H](O)[C@@]32[H]

• Molecular Weight:

  672.98

• References & Citations:

  [1]Liping Yu, et al. Novel pyxinol amide derivatives bearing an aliphatic heterocycle as P-glycoprotein modulators for overcoming multidrug resistance. Eur J Med Chem. 2024 Jun 5:272:116466.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported