P-gp-IN-30

CAT: 0804-HY-175206Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175206Size:1 Each
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Description
P-gp-IN-30 (Compound 13) is a P-glycoprotein (P-gp) inhibitor by targeting YB-1. P-gp-IN-30 significantly enhances sensitivity to Paclitaxel by reducing total YB-1 and nucleus YB-1 protein expression, inhibiting the expression and function of downstream P-gp, further suppressing the efflux rate of Paclitaxel. P-gp-IN-30 potently inhibits tumor growth in A549/Taxol xenografts mice model with combination of Paclitaxel (HY-B0015) . P-gp-IN-30 can be used for non-small cell lung cancer (NSCLC) research[1].
CAS Number
[2761881-65-4]
UNSPSC
12352005
Target
P-glycoprotein
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Smiles
CCOC(C1([C@]2(C3=CC=CC=C3NC2=O)[C@H](C4=CC=CC=C4)[C@@H](C5=CC[C@@]6([H])[C@]5([H])[C@H](OC)OC=C6C(OC)=O)N1)C(OCC)=O)=O
Molecular Formula
C34H36N2O9
Molecular Weight
616.66
References & Citations
[1]Deng L, et al. Discovery of a novel Genipin derivative targeting YB-1 to enhance the P-glycoprotein-mediated paclitaxel sensitivity of paclitaxel-resistant non-small cell lung cancer. Eur J Med Chem. 2025 Jun 27;297:117910.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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