P-gp modulator 1

• Description :

  P-gp modulator 1 is a high affinity, orally available modulator of P-glycoprotein (Pgp), can reverse the Pgp-mediated multidrug resistance ((MDR) [1].

• UNSPSC :

  12352005

• Target :

  P-glycoprotein

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/p-gp-modulator-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C)(O)[C@H](O1)CC[C@@]1(C)[C@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](NC(CCCCCNC(OC(C)(C)C)=O)=O)CC[C@]5(C)[C@@]4([H])C[C@@H](O)[C@@]32[H]

• Molecular Formula :

  C41H72N2O6

• Molecular Weight :

  689.02

• References & Citations :

  [1]Ren Q, et al. Design, synthesis, and discovery of ocotillol-type amide derivatives as orally available modulators of P-glycoprotein-mediated multidrug resistance. Eur J Med Chem. 2019 Jan 1;161:118-130.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2249749-39-9]