P-gp-IN-32

CAT: 0804-HY-175838Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175838Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
P-gp-IN-32 is a P-glycoprotein (P-gp) inhibitor. P-gp-IN-32 exhibits low cytotoxicity and potent multidrug resistance (MDR) reversal activity against Doxorubicin (HY-15142A) in MCF7/ADR cells (IC50 = 0.11 μM, reversal fold (RF) = 215.9) . P-gp-IN-32 can bind to P-gp directly, induce a conformation change of P-gp and inhibit the efflux function. P-gp-IN-32 can be used for the research of cancer, such as breast cancer[1].
CAS Number
[2918249-59-7]
UNSPSC
12352005
Target
P-glycoprotein
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
COC1=CC(C2=CC3=C(N(C(C(N4CCC5=C(C4)C=C(C(OC)=C5)OC)=O)=C3)CC6=CC=C(C=C6)OC)C=C2)=CC=C1
Molecular Formula
C35H34N2O5
Molecular Weight
562.65
References & Citations
[1]Yang Z, et al. Rational discovery of novel tetrahydroisoquinoline-indole derivatives as potent P-glycoprotein inhibitor against multidrug resistance in MCF-7/ADR cell. Bioorg Chem. 2025 Aug 9;164:108854.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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