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P-gp inhibitor 30

CAT: 0804-HY-178349Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178349Size:1 Each
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Description
P-gp inhibitor 30 is a potent P-gp inhibitor that reverses multidrug resistance in breast cancer by sensitizing resistant cells to Doxorubicin (ADM). P-gp inhibitor 30 promotes apoptosis, induces autophagy, and suppresses proliferation, migration, and invasion of drug-resistant breast cancer cells when combined with ADM. P-gp inhibitor 30 inhibits breast tumor growth both in vitro and in vivo. P-gp inhibitor 30 can be used for drug-resistant breast cancer research[1].
UNSPSC
12352005
Target
Apoptosis; Autophagy; P-glycoprotein
Related Pathways
Apoptosis; Autophagy; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
N#CC1=CC(NC(C2=NNC3=C2C=CC=C3)=O)=CC=C1OCC4=C(C=CC=C4)F
Molecular Formula
C22H15FN4O2
Molecular Weight
386.38
References & Citations
[1]Xue WH, et al. Discovery of a heterocyclic aromatic amide based P-gp inhibitor as coadjutant regulating autophagy against drug resistance in breast cancer. Eur J Med Chem. 2025 Dec 15;300:118151.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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