P-gp modulator-7

• Description:

  P-gp modulator-7 (Compound 9e) is a P-glycoprotein (P-gp) inhibitor. P-gp modulator-7 occupies the channel entrance of P-gp with a unique T-shaped configuration, hindering the peristaltic extrusion mechanism of transmembrane domains TM12 and TM9, thereby inhibiting P-gp from pumping drugs out of cells and reversing the multidrug resistance (MDR) of tumor cells. P-gp modulator-7 is promising for research of cancers[1].

• UNSPSC:

  12352005

• Target:

  P-glycoprotein

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Cancer

• Smiles:

  O=C (O[C@@H]1C[C@@]2 ([C@]3 (CCC (C (C) ([C@]3 ([H]) CC[C@]2 ([C@@]4 (CC[C@] ([C@]5 (C) CC[C@H] (O5) C (C) (O) C) ([C@@]14[H]) [H]) C) C) C) =O) C) [H]) CN6CCNCC6

• Molecular Formula:

  C36H60N2O5

• Molecular Weight:

  600.87

• References & Citations:

  [1]Chen C, et al. Design, synthesis, and biological evaluation of C-12 modified ocotillol-type derivatives as novel P-glycoprotein modulators for overcoming multidrug resistance. Eur J Med Chem. 2025 Sep 15;294:117757.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported