P-gp modulator-7

CAT: 0931-T207524-01Size: 10 mgDry Ice: NoHazardous: No

CAT#:0931-T207524-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

P-gp

Related Pathways

Neuroscience|||Membrane transporter/Ion channel

Bioactivity

P-gp modulator-7 (Compound 9e) is an inhibitor of P-glycoprotein (P-gp) . It uniquely occupies the channel entrance of P-gp in a T-shaped conformation, blocking the peristaltic extrusion mechanism of transmembrane domains TM12 and TM9. This action inhibits P-gp from pumping drugs out of cells and reverses multidrug resistance (MDR) in tumor cells. P-gp modulator-7 shows promise for cancer research.

Molecular Formula

C36H60N2O5

Shipping Conditions

Cool pack

Storage Temperature

-20°C

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P-gp modulator-7

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