Antitumor agent-168

CAT: 0804-HY-162695Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-162695Size:1 Each
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Description
Antitumor agent-168 (compound 21b) disrupts the microtubule network in tumor cells leading to G2/M cell cycle arrest and apoptosis induction. Antitumor agent-168 inhibits MCF-7 growth with an IC50 value of 1.4 nM[1].
CAS Number
[9007-83-4]
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-168.html
Smiles
NC1=CC(C2=CC=C3C(N(C4=CC(OC)=C(OC)C(OC)=C4)C=N3)=N2)=CC=C1C
Molecular Formula
C22H22N4O3
Molecular Weight
390.44
References & Citations
[1]Fuhao Jiang, et al. Discovery of Novel Diaryl-Substituted Fused Heterocycles Targeting Katanin and Tubulin with Potent Antitumor and Antimultidrug Resistance Efficacy. J Med Chem. 2024 Jul 25;67 (14)
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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