Antitumor agent-37

• Description :

  Antitumor agent-37 possesses potent anti-proliferative and anti-metastasis activities. Antitumor agent-37 induces serious DNA damage and further leads to high expression of γ-H2AX and p53. Antitumor agent-37 promotes apoptosis of tumor cells through mitochondrial apoptotic pathway Bcl-2/Bax/caspase3. Antitumor agent-37 significantly improves immune response through restraining the expression of PD-L1 to increase CD3+ and CD8+ T infiltrating cells in tumor tissues[1].

• CAS Number :

  [3032101-64-4]

• UNSPSC :

  12352300

• Target :

  Apoptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/antitumor-agent-37.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O[Pt](Cl)([NH3])(Cl)([NH3])O)C(C1=CC(C(C2=CC=CC=C2)=O)=CC=C1)C

• Molecular Formula :

  C16H20Cl2N2O4Pt

• Molecular Weight :

  570.33

• References & Citations :

  [1]Li Z, et al. Ketoprofen and Loxoprofen Platinum (IV) Complexes Displaying Antimetastatic Activities by Inducing DNA Damage, Inflammation Suppression, and Enhanced Immune Response. J Med Chem. 2021;64 (24) :17920-17935.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported