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Antitumor agent-37

CAT: 0804-HY-145289Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145289Size:1 Each
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Description
Antitumor agent-37 possesses potent anti-proliferative and anti-metastasis activities. Antitumor agent-37 induces serious DNA damage and further leads to high expression of γ-H2AX and p53. Antitumor agent-37 promotes apoptosis of tumor cells through mitochondrial apoptotic pathway Bcl-2/Bax/caspase3. Antitumor agent-37 significantly improves immune response through restraining the expression of PD-L1 to increase CD3+ and CD8+ T infiltrating cells in tumor tissues[1].
CAS Number
3032101-64-4
UNSPSC
12352300
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-37.html
Solubility
10 mM in DMSO
Smiles
O=C(O[Pt](Cl)([NH3])(Cl)([NH3])O)C(C1=CC(C(C2=CC=CC=C2)=O)=CC=C1)C
Molecular Formula
C16H20Cl2N2O4Pt
Molecular Weight
570.33
References & Citations
[1]Li Z, et al. Ketoprofen and Loxoprofen Platinum (IV) Complexes Displaying Antimetastatic Activities by Inducing DNA Damage, Inflammation Suppression, and Enhanced Immune Response. J Med Chem. 2021;64 (24) :17920-17935.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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