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Antitumor agent-172

CAT: 0804-HY-163768-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-163768-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antitumor agent-172 (Compound 28) is an inhibitor for β-catenin/BCL9 interaction with IC50 of 3.92 μM. Antitumor agent-172 exhibits high affinity to β-catenin with Kd of 82 nM. Antitumor agent-172 activates T cells, promotes antigen presentation, and exhibits antitumor efficacy and good pharmacokinetic characteristics in mouse models[1].
CAS Number
3027905-74-1
UNSPSC
12352005
Target
β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-172.html
Purity
98.51
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C(C)(OC1=CC(N2CCC[C@H](C2)NC(N(CC3=CC=C(C=C3)C4=CNN=C4)C5CC5)=O)=CC=C1)C)NCC(N6CCCC6CCN)=O
Molecular Formula
C37H50N8O4
Molecular Weight
670.84
References & Citations
[1]Zhu W, et al., Discovery of Novel 1-Phenylpiperidine Urea-Containing Derivatives Inhibiting β-Catenin/BCL9 Interaction and Exerting Antitumor Efficacy through the Activation of Antigen Presentation of cDC1 Cells. J Med Chem. 2024 Jun 24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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