PRMT5-IN-45

• UNSPSC Description:

  PRMT5-IN-45 (compound 36) is a potent and selective PRMT5 inhibitor with an IC50 of 3 nM. PRMT5-IN-45 potently reduces the level of symmetric dimethylarginines (sDMA) and inhibits the proliferation of MOLM-13 cell lines by inducing apoptosis and cell cycle arrest[1].

• Target Antigen:

  Apoptosis; Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Epigenetics

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/prmt5-in-45.html

• Smiles:

  O[C@@H]1[C@H](O)[C@@H](CCC2=CC=C3C=CC(N)=NC3=C2)C[C@H]1N4C=CC5=C(N6CCNCC6)N=CN=C54

• Molecular Weight:

  473.57

• References & Citations:

  [1]Huaxuan Li, et al. One stone two birds: Introducing piperazine into a series of nucleoside derivatives as potent and selective PRMT5 inhibitors. Eur J Med Chem. 2024 Oct 19:281:116970.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported