PRMT5-IN-52

CAT: 0804-HY-176534Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-176534Size:1 Each
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Description
PRMT5-IN-52 (Compound 17) is a non-nucleoside Protein Arginine Methyltransferase 5 (PRMT5) inhibitor with inhibitory rates of 20.2% at 10 μM. PRMT5-IN-52 has potent antitumor activity, promising for research of cancers, including lung, prostate cancer, and colorectal carcinoma[1].
CAS Number
[2783961-64-6]
UNSPSC
12352005
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
NC1=NC=NC2=C1C=C(C3=CC=C(OCC4=CC=CC=C4)C=C3)N2
Molecular Formula
C19H16N4O
Molecular Weight
316.36
References & Citations
[1]Rong D, et al. Structure-Aided Design, Synthesis, and Biological Evaluation of Potent and Selective Non-Nucleoside Inhibitors Targeting Protein Arginine Methyltransferase 5. J Med Chem. 2022 Jun 9;65 (11) :7854-7875.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT5

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