PRMT5-IN-52

• Description:

  PRMT5-IN-52 (Compound 17) is a non-nucleoside Protein Arginine Methyltransferase 5 (PRMT5) inhibitor with inhibitory rates of 20.2% at 10 μM. PRMT5-IN-52 has potent antitumor activity, promising for research of cancers, including lung, prostate cancer, and colorectal carcinoma[1].

• UNSPSC:

  12352005

• Target:

  Histone Methyltransferase

• Related Pathways:

  Epigenetics

• Field of Research:

  Cancer

• Smiles:

  NC1=NC=NC2=C1C=C(C3=CC=C(OCC4=CC=CC=C4)C=C3)N2

• Molecular Formula:

  C19H16N4O

• Molecular Weight:

  316.36

• References & Citations:

  [1]Rong D, et al. Structure-Aided Design, Synthesis, and Biological Evaluation of Potent and Selective Non-Nucleoside Inhibitors Targeting Protein Arginine Methyltransferase 5. J Med Chem. 2022 Jun 9;65 (11) :7854-7875.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PRMT5

• CAS Number:

  [2783961-64-6]