PRMT5-IN-53

CAT: 0804-HY-178028Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-178028Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
PRMT5-IN-53 is a gut-restricted and orally active PRMT5 inhibitor with pIC50s of ≥ 9.7 against hPRMT5 and mPRMT5. PRMT5-IN-53 binds to the PRMT5:MEP50 complex with a KD of 11.3 pM. PRMT5-IN-53 effectively inhibits PRMT5 locally in the intestines of mice, significantly reducing the number and area of polyps, while avoiding systemic hematological toxicity (such as anemia, neutropenia) . PRMT5-IN-53 can be used for the study of colorectal cancer especially for familial adenomatous polyposis (FAP) [1].
UNSPSC
12352005
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O[C@@H]1[C@H](O)[C@@H](CNC2=CC=C(C=CC(N)=N3)C3=C2)C[C@H]1N(C=C4)C5=C4C=NC=N5
Molecular Formula
C21H22N6O2
Molecular Weight
390.44
References & Citations
[1]Hulpia F, et al. Discovery of Gut-Restricted PRMT5 Inhibitors to Intercept Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor Adenomatous Polyposis Coli. J Med Chem. 2025 Aug 26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT5

Related Products

CatalogName
HY-163590PRMT5-IN-41
HY-153421PRMT5-IN-28
HY-160029PRMT5-IN-32
HY-160865-01PRMT5-IN-35
HY-168263PRMT5-IN-45
HY-144188PRMT5-IN-17
HY-144187PRMT5-IN-16
HY-144189PRMT5-IN-18
HY-150081PRMT5-IN-21
HY-163593PRMT5-IN-44

Alternative Products

CatalogName
sc-59650PRMT5 (PRMT5-21)
MBS8533547-01PRMT5
MBS8586682-01PRMT5 Antibody
DF6439-BPPRMT5 Peptide
MBS5800350PRMT5-IN-15
MBS5805812PRMT5-IN-16
MBS5819840PRMT5-IN-29
sc-136202PRMT5 (23C7)
YF-PA16949anti-PRMT5

Popular Products