PRMT5-IN-48

• Target :

  Histone Methyltransferase

• Related Pathways :

  Chromatin/Epigenetic

• Bioactivity :

  PRMT5-IN-48 (compound D3) is an orally active PRMT5 inhibitor with an IC50 of 20.7 nM, displaying antitumor activity. It effectively suppresses the growth of various cancer cells, induces apoptosis, and causes cell cycle arrest at the G0/G1 phase. PRMT5-IN-48 is applicable for research in non-Hodgkin's lymphoma (NHL) .

• Smiles :

  C([C@@H](CN1CC=2C(CC1)=CC=CC2)O)N3CC4(C=5C(C3=O)=CC(NC6CC7(C6)CN(C(C)=O)C7)=NC5)CC4

• Molecular Formula :

  C30H37N5O3

• Molecular Weight :

  515.646

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2640287-77-8