PRMT5-IN-51

• Description:

  PRMT5-IN-51 (compound 16–19F) is a potent PRMT5 inhibitor. PRMT5-IN-51 shows antiproliferative activity[1].

• UNSPSC:

  12352005

• Target:

  Histone Methyltransferase

• Related Pathways:

  Epigenetics

• Field of Research:

  Cancer

• Smiles:

  O=C(N1CC2=CC=C(C(N)=NC(N)=N3)C3=C2)CCC4=C1C(Cl)=CC=C4

• Molecular Formula:

  C18H16ClN5O

• Molecular Weight:

  353.81

• References & Citations:

  [1]Shen Z, et al. Discovery and Mechanism of 16-19F, a Novel Synthetic Lethal Inhibitor of the PRMT5•MTA Complex in MTAP-Deleted Cancer Cells. ACS Chem Biol. 2025 Jun 20;20 (6) :1333-1346.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  3064668-92-1