PF-5177624

• UNSPSC Description:

  PF-5177624 is a specific and potent inhibitor of PDK1, a key enzyme in the PI3K/AKT signaling pathway that is frequently dysregulated in breast cancer. PDK1 phosphorylates AKT at T308 and other substrates, activating downstream signaling pathways that are important for tumor progression. PF-5177624 blocks IGF-1-stimulated PDK1 activity and downstream AKT and p70S6K phosphorylation, reducing cell proliferation and transformation in breast cancer cells[1].

• Target Antigen:

  PDK-1

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/pf-5177624.html

• Smiles:

  O=CN1[C@@H]([C@@H](CC1)NC2=NC(C(C3=CN(C4=NC=NC(N)=C43)C(C)C)=O)=CN=C2)C5=CC=C(C=C5)F

• Molecular Weight:

  488.52

• References & Citations:

  [1]A novel and selective 3-phosphoinositide-dependent kinase-1 inhibitor, PF-5177624, blocks insulin-like growth factor-1 induced tumorigenesis in breast cancer cells

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1350821-45-2