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SB-203186

CAT: 0804-HY-135439Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-135439Size:1 Each
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Description
SB-203186 is a highly selective 5-HT4 receptor antagonist. SB-203186 exhibits a potent competitive antagonistic effect, with its pKB value being 8.3 in the isolated right atrium model of piglets. SB-203186 can dose-dependently shift the 5-HT-induced tachycardia curve to the right, and does not inhibit the maximum response. SB-203186 is an efficient 5-HT₄ antagonist in pig and human atria, but has no significant inhibitory effect in rat atria. SB-203186 can be used for the study of diseases such as arrhythmias and abnormal myocardial contraction[1][2].
CAS Number
[135938-17-9]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C1=CNC2=C1C=CC=C2)OCCN3CCCCC3
Molecular Formula
C16H20N2O2
Molecular Weight
272.34
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Medhurst AD, Kaumann AJ. Characterization of the 5‐HT4 receptor mediating tachycardia in piglet isolated right atrium. British journal of pharmacology. 1993 Nov;110 (3) :1023-30.|[2]Läer S, et al. Receptor mechanisms involved in the 5‐HT‐induced inotropic action in the rat isolated atrium. British journal of pharmacology. 1998 Mar;123 (6) :1182-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT4 Receptor

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