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SB-203186

CAT: 0804-HY-135439Size: 1 EachDry Ice: NoHazardous: No
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Description
SB-203186 is a highly selective 5-HT4 receptor antagonist. SB-203186 exhibits a potent competitive antagonistic effect, with its pKB value being 8.3 in the isolated right atrium model of piglets. SB-203186 can dose-dependently shift the 5-HT-induced tachycardia curve to the right, and does not inhibit the maximum response. SB-203186 is an efficient 5-HT₄ antagonist in pig and human atria, but has no significant inhibitory effect in rat atria. SB-203186 can be used for the study of diseases such as arrhythmias and abnormal myocardial contraction[1][2].
CAS Number
135938-17-9
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C1=CNC2=C1C=CC=C2)OCCN3CCCCC3
Molecular Formula
C16H20N2O2
Molecular Weight
272.34
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Medhurst AD, Kaumann AJ. Characterization of the 5‐HT4 receptor mediating tachycardia in piglet isolated right atrium. British journal of pharmacology. 1993 Nov;110 (3) :1023-30.|[2]Läer S, et al. Receptor mechanisms involved in the 5‐HT‐induced inotropic action in the rat isolated atrium. British journal of pharmacology. 1998 Mar;123 (6) :1182-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT4 Receptor

Chemical Information

1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride
CAS Number135938-17-9
PubChem CID9926639
IUPAC Name2-piperidin-1-ylethyl 1H-indole-3-carboxylate;hydrochloride
Molecular FormulaC16H21ClN2O2
Molecular Weight308.80
Topological Polar Surface Area45.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Heavy Atom Count21
Formal Charge0
Complexity328
SMILES
C1CCN(CC1)CCOC(=O)C2=CNC3=CC=CC=C32.Cl
InChI
InChI=1S/C16H20N2O2.ClH/c19-16(20-11-10-18-8-4-1-5-9-18)14-12-17-15-7-3-2-6-13(14)15;/h2-3,6-7,12,17H,1,4-5,8-11H2;1H
InChIKey
LYMBEMCUJNDSBZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride
CAS: 135938-17-9
CID: 9926639
Formula: C16H21ClN2O2
MW: 308.80
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight308.80
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass308.1291556
Monoisotopic Mass308.1291556
Topological Polar Surface Area45.3 Ų
Heavy Atom Count21
Formal Charge0
Complexity328
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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