Exatecan intermediate 11

• Description :

  Exatecan intermediate 11 is an intermediate for the synthesis of Exatecan (HY-13631) . Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM) [1].

• UNSPSC :

  12352203

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  ADC Payload; Topoisomerase

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/exatecan-intermediate-11.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1=C2C(C(/C(CC2)=N\O)=O)=C(NC(C)=O)C=C1F

• Molecular Formula :

  C13H13FN2O3

• Molecular Weight :

  264.25

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Camptothecins