Exatecan Intermediate 5

• Description:

  Exatecan Intermediate 5 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 5 can be used to synthesize Antibody-Drug Conjugates (ADCs) .

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  ADC Payload; Topoisomerase

• Type:

  Reference compound

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/exatecan-intermediate-5.html

• Purity:

  99.98

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  FC1=CC(NC(C)=O)=C(C(C(NC(C)=O)CC2)=O)C2=C1C

• Molecular Formula:

  C15H17FN2O3

• Molecular Weight:

  292.31

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Xu, et al. Preparation of exatecan intermediate and its application. China, CN115701419 A. 2023-02-10.|[2]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Camptothecins

• CAS Number:

  [143655-70-3]