Exatecan Intermediate 5

• Description :

  Exatecan Intermediate 5 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 5 can be used to synthesize Antibody-Drug Conjugates (ADCs) .

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  ADC Payload; Topoisomerase

• Type :

  Reference compound

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/exatecan-intermediate-5.html

• Purity :

  99.98

• Solubility :

  DMSO : 25 mg/mL (ultrasonic)

• Smiles :

  FC1=CC(NC(C)=O)=C(C(C(NC(C)=O)CC2)=O)C2=C1C

• Molecular Formula :

  C15H17FN2O3

• Molecular Weight :

  292.31

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Xu, et al. Preparation of exatecan intermediate and its application. China, CN115701419 A. 2023-02-10.|[2]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Camptothecins

• CAS Number :

  [143655-70-3]