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Exatecan Intermediate 5

CAT: 804-HY-43564-01Size: 25 mgDry Ice: NoHazardous: No
25 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Exatecan Intermediate 5 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 5 can be used to synthesize Antibody-Drug Conjugates (ADCs) .
CAS Number
[143655-70-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ADC Payload; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/exatecan-intermediate-5.html
Purity
99.98
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
FC1=CC(NC(C)=O)=C(C(C(NC(C)=O)CC2)=O)C2=C1C
Molecular Formula
C15H17FN2O3
Molecular Weight
292.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Xu, et al. Preparation of exatecan intermediate and its application. China, CN115701419 A. 2023-02-10.|[2]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Camptothecins

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