Exatecan intermediate 9

CAT: 0931-MF-0122423-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0122423-01Size:10 mg
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CAS Number
2290562-59-1
Target
ADC Cytotoxin
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
Exatecanintermediate 9 is an intermediate used in the synthesis of Exatecan. Exatecan (DX-8951) is a common toxin component in the preparation of Antibody-Drug Conjugates (ADC Cytotoxin) and also acts as an inhibitor of DNA topoisomerase I (topoisomerase I), with an inhibition concentration (IC50) of 2.2 ?M.
Smiles
N(C(C)=O)C1C2=C3C(C=4N(C3)C(=O)C5=C(C4)[C@](CC)(O)C(=O)OC5)=NC=6C2=C(CC1)C(C)=C(F)C6
Molecular Formula
C26H24FN3O5
Molecular Weight
477.48
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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