Exatecan intermediate 8

• Description :

  Exatecan intermediate 8 is an intermediate for the synthesis of Exatecan (HY-13631) . Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM) [1].

• UNSPSC :

  12352203

• Target :

  ADC Payload; Topoisomerase

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/exatecan-intermediate-8.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=S(C)(O)=O.O=C1[C@@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5NC(OC(C)(C)C)=O)C(C)=C(F)C=C6N=C4C3=C2)=O

• Molecular Formula :

  C30H34FN3O9S

• Molecular Weight :

  631.67

• References & Citations :

  [1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Camptothecins