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Exatecan Intermediate 1

CAT: 0804-HY-42487-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-42487-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan. Exatecan is a DNA topoisomerase I inhibitor with anticancer effects[1][2][3].
CAS Number
110351-94-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ADC Payload; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/exatecan-intermediate-1.html
Purity
99.99
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1[C@](O)(CC)C(C=C23)=C(CO1)C(N3CCC2=O)=O
Molecular Formula
C13H13NO5
Molecular Weight
263.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13 (4) :950-973. |[2]Zhang Hongwei, et al. Intermediate for synthesizing camptothecin derivatives using exatecan mesylate and its preparation method and application. China, CN111470998. 2020-07-31. |[3]Conilh L, et al. Exatecan Antibody Drug Conjugates Based on a Hydrophilic Polysarcosine Drug-Linker Platform. Pharmaceuticals (Basel) . 2021 Mar 9;14 (3) :247.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Camptothecins

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