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Exatecan Intermediate 7

CAT: 0804-HY-45157-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0804-HY-45157-01Size:25 mg
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Description
Exatecan Intermediate 7 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 7 can be used to synthesize Antibody-Drug Conjugates (ADCs) .
CAS Number
[182182-32-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ADC Payload; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/exatecan-intermediate-7.html
Concentration
10mM
Purity
99.24
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(NC(C=C(F)C(C)=C1CC/C2=N\O)=C1C2=O)=O
Molecular Formula
C13H13FN2O3
Molecular Weight
264.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Kamihara, et al. Aminotetralone derivatives and process for producing the same. World Intellectual Property Organization, WO9626181 A1 1996-08-29.|[2]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Camptothecins

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