RB-07-16

• Description:

  RB-07-16 is a C6-PyraP-BP inhibitor of human geranylammate pyrophosphate synthase (hGGPPS) . RB-07-16 has antitumor activity[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/rb-07-16.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN1N=CC2=C1N=C(C3=CC=CC(C(NC4=CC=C(C(F)(F)F)C=C4)=O)=C3)N=C2NC(P(O)(O)=O)P(O)(O)=O

• Molecular Formula:

  C21H19F3N6O7P2

• Molecular Weight:

  586.35

• References & Citations:

  [1]Rebecca Boutin, et al. Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor Efficacy in Multiple Myeloma, Pancreatic Ductal Adenocarcinoma, and Colorectal Cancer. J Med Chem. 2023, 66, 23.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported