LZ-07

CAT: 0804-HY-172590Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-172590Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
LZ-07 is a IRAK4 PROTAC degrader (DC50 = 1.14 nM) . LZ-07 leads to marked suppression of cytokines including IL-6, IL-1β, TNF-α, and IL-10 upon degradation of IRAK4. LZ-07 can be studied in research for autoimmune diseases (Pink: IRAK4 ligand (HY-172591) ; Blue: CRBN ligand (HY-34590) ; Black: linker (HY-B0149) ; CRBN ligand + linker: HY-172593) [1].
UNSPSC
12352005
Target
Interleukin Related; IRAK; PROTACs; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CC1(CC1)NC2=NC(NC3=CN(C4CCN(C([C@@H]5CC[C@@H](CNC6=CN=C(C(NC7CCC(NC7=O)=O)=O)C=C6)CC5)=O)CC4)N=C3)=NC8=CC=C(C9=CN=CN=C9)N=C82
Molecular Formula
C42H48N14O4
Molecular Weight
812.92
References & Citations
[1]Zhen Li, et al., Developing potent anti-inflammatory IRAK4-targeting PROTACs with simplified CRBN ligands, Chinese Chemical Letters, 2025, 111033, ISSN 1001-8417.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-D1383LZ-1105
HY-168713LZ-007
HY-N14923Nikkomycin Lz
HY-162886BSO-07
HY-106156Allotrap 07
HY-108003-01MM 07
HY-144308RMS-07
HY-149495CP-07
HY-125158HOI-07
HY-163912JZD-07

Alternative Products

CatalogName
MF-0114708-01LZ-07
MF-0112114-01LZ-007
MF-0125957-01Nikkomycin Lz
STJ501223Anti-07/02/07
C18069SH5-07 (SH-5-07)
MBS1320132Recombinant Drosophila melanogaster Protein lozenge (lz), partial
M30642-01MM 07
MF-0018047-01SH5-07
MF-0094290-01KCC-07
MF-0062154-01AFP-07

Popular Products