LZ-07

• Description:

  LZ-07 is a IRAK4 PROTAC degrader (DC50 = 1.14 nM) . LZ-07 leads to marked suppression of cytokines including IL-6, IL-1β, TNF-α, and IL-10 upon degradation of IRAK4. LZ-07 can be studied in research for autoimmune diseases (Pink: IRAK4 ligand (HY-172591) ; Blue: CRBN ligand (HY-34590) ; Black: linker (HY-B0149) ; CRBN ligand + linker: HY-172593) [1].

• UNSPSC:

  12352005

• Target:

  Interleukin Related; IRAK; PROTACs; TNF Receptor

• Related Pathways:

  Apoptosis; Immunology/Inflammation; PROTAC

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  CC1(CC1)NC2=NC(NC3=CN(C4CCN(C([C@@H]5CC[C@@H](CNC6=CN=C(C(NC7CCC(NC7=O)=O)=O)C=C6)CC5)=O)CC4)N=C3)=NC8=CC=C(C9=CN=CN=C9)N=C82

• Molecular Formula:

  C42H48N14O4

• Molecular Weight:

  812.92

• References & Citations:

  [1]Zhen Li, et al., Developing potent anti-inflammatory IRAK4-targeting PROTACs with simplified CRBN ligands, Chinese Chemical Letters, 2025, 111033, ISSN 1001-8417.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported