16(R)-AFP 07 (free acid)

16(R)-AFP 07 (free acid)

• CAS Number: 773825-80-2
• UNSPSC Description: Prostaglandin I2 is an unstable prostanoid which, through the ‘I prostanoid’ (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki=0.561 nM).1 AFP 07 shows weaker affinity for EP receptors, with Ki values > 100 nM for EP1-3 and > 10 nM for EP4. 16(R)-AFP 07 is an epimer of AFP 07. Its biological properties, particularly through the IP and EP receptors, remain to be evaluated.
• Target Antigen: Prostaglandin Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Endocrinology
• Assay Protocol: https://www.medchemexpress.com/16-r-afp-07-free-acid.html
• Smiles: O=C(O)CCC/C=C1C(F)(F)[C@@]([C@@H](/C=C/[C@H](O)[C@@H](C)CC#CCC)[C@H](O)C2)([H])[C@@]2([H])O/1
• Molecular Weight: 412.47
• References & Citations: [1]Chang, et al. 7,7-Difluoroprostacyclin derivative, AFP-07, a highly selective and potent agonist for the prostacyclin receptor. Prostaglandins 53(2), 83-90 (1997).
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported