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KCC-07

CAT: 0804-HY-131031-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131031-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KCC-07 is a potent and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. Anticancer activity[1].
CAS Number
315702-75-1
UNSPSC
12352005
Hazard Statement
H302, H319
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kcc-07.html
Purity
99.97
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC1=CC=CC(NC2=NC(C3=NC=CC=C3)=CS2)=C1
Molecular Formula
C14H11N3OS
Molecular Weight
269.32
Precautions
H302, H319
References & Citations
[1]Dan Zhu, et al. BAI1 Suppresses Medulloblastoma Formation by Protecting p53 From Mdm2-Mediated Degradation. Cancer Cell. 2018 Jun 11;33 (6) :1004-1016.e5.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

3-[(4-Pyridin-2-yl-1,3-thiazol-2-yl)amino]phenol
CAS Number315702-75-1
PubChem CID704347
IUPAC Name3-[(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]phenol
Molecular FormulaC14H11N3OS
Molecular Weight269.32
XLogP3.1
Topological Polar Surface Area86.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count19
Formal Charge0
Complexity292
SMILES
C1=CC=NC(=C1)C2=CSC(=N2)NC3=CC(=CC=C3)O
InChI
InChI=1S/C14H11N3OS/c18-11-5-3-4-10(8-11)16-14-17-13(9-19-14)12-6-1-2-7-15-12/h1-9,18H,(H,16,17)
InChIKey
GIGNWEDIMLUWCT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-[(4-Pyridin-2-yl-1,3-thiazol-2-yl)amino]phenol
CAS: 315702-75-1
CID: 704347
Formula: C14H11N3OS
MW: 269.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight269.32
XLogP33.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass269.06228316
Monoisotopic Mass269.06228316
Topological Polar Surface Area86.3 Ų
Heavy Atom Count19
Formal Charge0
Complexity292
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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