KCC-07

• Description :

  KCC-07 is a potent and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. Anticancer activity[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H319

• Target :

  DNA Alkylator/Crosslinker

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/kcc-07.html

• Purity :

  99.97

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  OC1=CC=CC(NC2=NC(C3=NC=CC=C3)=CS2)=C1

• Molecular Formula :

  C14H11N3OS

• Molecular Weight :

  269.32

• Precautions :

  H302, H319

• References & Citations :

  [1]Dan Zhu, et al. BAI1 Suppresses Medulloblastoma Formation by Protecting p53 From Mdm2-Mediated Degradation. Cancer Cell. 2018 Jun 11;33 (6) :1004-1016.e5.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [315702-75-1]