HOI-07

• Description :

  HOI-07 is a selective Aurora B kinase inhibitor. HOI-07 blocks phosphorylation of histone H3 on Ser10 in lung cancer cells. HOI-07 induces cell-cycle arrest, and apoptosis. HOI-07 has antitumor activity, and suppresses the tumor growth of A549, 143B and KHOS xenografts[1][2].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Aurora Kinase

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Smiles :

  O=C1NC2=C(/C1=C\C(/C=C/C3=CC=C4OCOC4=C3)=O)C=CC=C2

• Molecular Formula :

  C19H13NO4

• Molecular Weight :

  319.31

• References & Citations :

  [1]Xie H, et al. Identification of an Aurora kinase inhibitor specific for the Aurora B isoform. Cancer Res. 2013 Jan 15;73 (2) :716-24.|[2]Zhao Z, et al. Aurora B kinase as a novel molecular target for inhibition the growth of osteosarcoma. Mol Carcinog. 2019 Jun;58 (6) :1056-1067.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1451013-67-4]