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HOI-07

CAT: 0804-HY-125158Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-125158Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HOI-07 is a selective Aurora B kinase inhibitor. HOI-07 blocks phosphorylation of histone H3 on Ser10 in lung cancer cells. HOI-07 induces cell-cycle arrest, and apoptosis. HOI-07 has antitumor activity, and suppresses the tumor growth of A549, 143B and KHOS xenografts[1][2].
CAS Number
1451013-67-4
UNSPSC
12352005
Target
Apoptosis; Aurora Kinase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1NC2=C(/C1=C\C(/C=C/C3=CC=C4OCOC4=C3)=O)C=CC=C2
Molecular Formula
C19H13NO4
Molecular Weight
319.31
References & Citations
[1]Xie H, et al. Identification of an Aurora kinase inhibitor specific for the Aurora B isoform. Cancer Res. 2013 Jan 15;73 (2) :716-24.|[2]Zhao Z, et al. Aurora B kinase as a novel molecular target for inhibition the growth of osteosarcoma. Mol Carcinog. 2019 Jun;58 (6) :1056-1067.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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GTR19209578-01HOI-07
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