RMS-07

CAT: 0804-HY-144308Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-144308Size:1 Each
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Description
RMS-07 is a covalent Monopolar Spindle Kinase 1 (MPS1/TTK) inhibitor, with an apparent IC50 of 13.1 nM. RMS-07 targets a poorly conserved cysteine in the kinase's hinge region[1].
CAS Number
[2645409-78-3]
UNSPSC
12352005
Target
Mps1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/rms-07.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2CCC3=CN=C(NC4=CC=C(N5CCN(C)CC5)C=C4NC(C=C)=O)N=C3N2C=C1)NC6=C(CC)C=CC=C6CC
Molecular Formula
C35H40N8O2
Molecular Weight
604.74
References & Citations
[1]Ricardo A M Serafim, et al. Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor. J Med Chem. 2022 Feb 24;65 (4) :3173-3192.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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