RMS-07

• UNSPSC Description:

  RMS-07 is a covalent Monopolar Spindle Kinase 1 (MPS1/TTK) inhibitor, with an apparent IC50 of 13.1 nM. RMS-07 targets a poorly conserved cysteine in the kinase's hinge region[1].

• Target Antigen:

  Mps1

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/rms-07.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=C2CCC3=CN=C(NC4=CC=C(N5CCN(C)CC5)C=C4NC(C=C)=O)N=C3N2C=C1)NC6=C(CC)C=CC=C6CC

• Molecular Weight:

  604.74

• References & Citations:

  [1]Ricardo A M Serafim, et al. Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor. J Med Chem. 2022 Feb 24;65(4):3173-3192.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2645409-78-3